Replenish the source within
نویسندگان
چکیده
We have recently reported that the PD-1 and CTLA4 signaling pathways are active in both effector and regulatory T cells, causing profound immune dysfunctions in the tumor microenvironment. In line with this notion, the dual blockade of PD-1- and CTLA4-conveyed signals may exert robust therapeutic effects. Here, we discuss the mechanisms possibly underlying such a synergic interaction.
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عنوان ژورنال:
دوره 2 شماره
صفحات -
تاریخ انتشار 2013